Medical Chemistry and Biochemistry

Medical Biochemistry has an irreplaceable role in study of General Medicine. The students should learn about biochemical reactions in all living systems, especially in the human body. The knowledge will help them later to diagnose and treat many diseases correctly. In firsts semester is study concentrated to metabolic processes connected with metabolism of nutrients (e.g. saccharides, lipids, proteins, nucleic acids). In second semester is teaching focused to study metabolism of organs (e.g. liver, kidney, muscles, hard tissue, skin), chemical communications and introduction to Clinical Biochemistry.

Medical Biochemistry has an irreplaceable role in study of Dental Medicine. The students should learn about biochemical reactions taking place in the human body. The knowledge will help them better understand processes take place in the mouth. In firsts semester is study concentrated to metabolic processes connected with metabolism of nutrients (e.g. saccharides, lipids, proteins, nucleic acids). In second semester is teaching focused to study metabolism of organs (e.g. liver, kidney), hard tissue and to oral biochemistry and pathobiochemistry (e.g. dental plaque, tooth decay and tartar).

The subject Chemistry of Dental Materials includes selected chapters from general, inorganic, and physical chemistry. Teaching focuses mainly on introduction to the study of the chemical properties of materials routinely used in dentistry. The lectures are focused on selected parts of the study of metals, including noble metals and their alloys. Furthermore, attention is focused on ceramic materials, on dental cements, as well as on polymerization and substances resulting from polymerization and used in dentistry for both restorative and prosthetic purposes. Information about dental materials, auxiliary dental materials, as well as the importance of polymerization in dentistry is crucial for future dentists.

Practical exercises from Chemistry of Dental Materials is a set of experimental exercises designed for a better understanding of the subject. Practical experimental tasks enable students to become familiar with the basic chemical calculation and with chemical properties of materials commonly used in dentistry. They contribute to a better understanding of the properties of e.g., hydroxyapatite, metal corrosion and other properties of elements contained in dental materials. Separate attention is paid to dental plaster – its preparation and properties. Laboratory manuals for the practical exercises are arranged into weeks according to the syllabus and contain theoretical introduction as well as experimental procedures for each exercise.

Knowledge of the structure and function of chemical substances and compounds, as well as their interactions and factors which can influence these interactions are very important for study Medical Chemistry and Biochemistry. The supporting materials is based on the secondary school curriculum of chemistry, and represent the summarization of knowledge’s from high school, extended by new knowledge necessary especially for the subsequent study of medical biochemistry. The repetitorium is divided into several chapters and represents a summary of knowledge focused mainly on bioorganic chemistry, including structures, nomenclature and typical reactions.

The laboratory manuals are developed to the foreign students of medicine for practical laboratory exercise and verification of knowledge from medical biochemistry. Exercises are arranged into weeks in winter term (WT) and summer term (ST), like it is in Syllabus of Lectures and practical exercises (WT, ST). Students can apply their manual skill in performing of the experiments, and also train their ability in evaluation of results and making of diagnoses.

Revised and supplemented first published version “Practical exercises from biochemistry”. Authors: Tomečková V., Kron I., Mareková M., Pavol Jozef Šafárik University in Košice, Košice 2011, ISBN 978-80-7097-874-0.

Practical exercises from Medical Chemistry is a set of experimental exercises designed for a better understanding of the subject. Laboratory manuals for the practical exercises are arranged into weeks according to the syllabus (WT) and contain theoretical introduction as well as experimental procedures for each exercise. Published material represents an effective instrument for understanding of the basic principles of Medical Chemistry.

Revised and supplemented first published version “Practical exercises from Medical Chemistry”. Authors: Stupák M., Rabajdová M., Mašlanková J., Urban P., Tomečková V., Mareková M.

The electronic textbook "Clinical Biochemistry - Selected Chapters" aims to be a practical resource for senior medical students and new doctors studying laboratory medicine. It is designed to help them understand commonly used clinical-biochemical tests and serves as a starting point for a deeper exploration of laboratory methods and their application in diagnostic and monitoring procedures. In addition to an introductory chapter, the textbook contains 13 chapters focusing on disorders of water-ion and acid-base balance, biochemical diagnosis of various organ-related diseases (kidneys, liver, heart, thyroid gland, and adrenal glands), as well as common conditions like diabetes and dyslipidemia. It also covers topics, such as inflammation, oncological diseases, and iron and heme metabolism. The second edition of the textbook has been updated to reflect current changes in professional recommendations and to be more understandable for users.

ISBN 978-80-8152-937-5 (e-publication); www.unibook.upjs.sk; https://unibook.upjs.sk/img/cms/2020/lf/clinical-biochemistry.pdf

The Clinical Biochemistry subject in the 5th year of medical studies builds on the knowledge acquired in Medical Biochemistry during the 2nd year. It involves applying biochemistry and pathobiochemistry to laboratory findings interpretation. The subject covers biochemical investigation methods for diseases of selected organs through lectures and seminars. It places particular emphasis on water, ion, and acid-base balance disorders, as well as prevalent conditions like diabetes mellitus and dyslipidemia. Practical training in interpreting laboratory findings integrates patient case studies and model patients.

This publication is intended mainly for students of medicine studying at the UPJŠ in Košice, Faculty of Medicine. The textbook covers the basic knowledge of selected topics of general, physical, inorganic, organic and bioorganic chemistry required for successful completion of the course of Medical Chemistry. Knowledge of the structures and functions of chemical substances and compounds, as well as their interactions and factors of surroundings influencing those interactions is very important for next study medical biochemistry incoming physicians. For better and easier understanding is the text appropriately supplemented with figures, tables, and numerous of chemical schemes. The separate part of this publication presents the chemistry of the most important dental materials used in clinical practise of future dentists, including the properties of metals, polymers and impression materials.