Medical Chemistry and Biochemistry

The Clinical Biochemistry subject in the 5th year of medical studies builds on the knowledge acquired in Medical Biochemistry during the 2nd year. It involves applying biochemistry and pathobiochemistry to laboratory findings interpretation. The subject covers biochemical investigation methods for diseases of selected organs through lectures and seminars. It places particular emphasis on water, ion, and acid-base balance disorders, as well as prevalent conditions like diabetes mellitus and dyslipidemia. Practical training in interpreting laboratory findings integrates patient case studies and model patients.

This publication is intended mainly for students of medicine studying at the UPJŠ in Košice, Faculty of Medicine. The textbook covers the basic knowledge of selected topics of general, physical, inorganic, organic and bioorganic chemistry required for successful completion of the course of Medical Chemistry. Knowledge of the structures and functions of chemical substances and compounds, as well as their interactions and factors of surroundings influencing those interactions is very important for next study medical biochemistry incoming physicians. For better and easier understanding is the text appropriately supplemented with figures, tables, and numerous of chemical schemes. The separate part of this publication presents the chemistry of the most important dental materials used in clinical practise of future dentists, including the properties of metals, polymers and impression materials.

Proper administration of individual medications and reagents is of the upmost importance in the clinical practice of future doctors. It can be affected by age, body weight, kidney and liver health, and other health conditions. Subject Medical Chemistry is therefore an essential part of the theoretical education at medical faculties. The basics for the successful completion of the course are also basic chemistry calculations including solution preparation, stoichiometric calculations, pH calculations (including buffers) and spectrophotometric calculations. In addition to brief theoretical introductions, the material also contains a series of examples for practice, in order to help students in repeating and preparing for the exam from Medical Chemistry.

Need of carrying out a pharmacological genotyping for providing the individualized pharmacotherapy is shown in the monograph based on the analysis of own and literary data of the central link of drug pharmacokinetics– systems of cytochrome P-450, taking into account its genetic polymorphysm. The monograph is intended for the clinical pharmacologists, geneticists and experts dealing with this problem.

Mavlyanov I.R., Ashirmetov A.Kh., Mavlyanov Z.I., Jarilkasinova G.J.: CYTOCHROME P-450: genetic and population aspects, Pavol Jozef Šafárik University in Košice, Košice 2017, ISBN 978-80-8152-526-1.